Palladium-catalyzed asymmetric conjugate addition of arylboronic acids to heterocyclic acceptors.

نویسندگان

  • Jeffrey C Holder
  • Alexander N Marziale
  • Michele Gatti
  • Bin Mao
  • Brian M Stoltz
چکیده

Flava Flavanone: Asymmetric conjugate additions to chromones and 4-quinolones are reported utilizing a single catalyst system formed in situ from Pd(OCOCF(3))(2) and (S)-tBuPyOX. Notably, these reactions are performed in wet solvent under ambient atmosphere, and employ readily available arylboronic acids as the nucleophile, thus providing ready access to these asymmetric heterocycles (see scheme).

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عنوان ژورنال:
  • Chemistry

دوره 19 1  شماره 

صفحات  -

تاریخ انتشار 2013